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The two extra ligands afforded by the low-spin d 6 platinum(IV) center provide a means to impart and fine-tune desirable biological properties such as lipophilicity, redox stability, specific targeting, orthogonal bioactivity, and improved cellular uptake

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It was found that the toxic effect of sorafenib on hepatocellular carcinoma cells was partly dependent on ferroptosis rather than apoptosis, and this toxic effect was also not dependent on its multikinase inhibitory activity, but induced ferroptosis by inducing iron aggregation and lipid peroxidation stress in hepatocellular carcinoma cells, and that depletion of stored iron in hepatocellular carcinoma cells by use of iron chelating agents could effectively weaken the cytotoxic effect of sorafenib

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To fuse or not to fuse: what is your purpose