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A deficiency of l-carnitine can lead to impaired mitochondrial function and cellular metabolic alterations that may underlie many disease states

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Dikalova A.E., Pandey A., Xiao L., Arslanbaeva L., Sidorova T., Lopez M.G., Billings F.T., Verdin E., Auwerx J., Harrison D.G., et al

Four small molecules [sulfamethoxazole, ketoprofen, MES (4- morpholineethanesulfonic acid), glyphosate], and 4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) were used for the spiking sample, and Acetyl-d3-L-carnitine hydrochloride used as the internal standard in selected reaction monitoring (SRM) analysis was purchased from Sigma-Aldrich (St