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The GutBrainMitochondria Axis in Autism The process can be understood as a biological cascade: Gut dysbiosis imbalance in the microbiome Leaky gut increased intestinal permeability Microbial metabolites enter the bloodstream Neuroinflammation and oxidative stress occur in the brain Mitochondrial dysfunction affects neuronal development This interconnected system helps explain why many children with ASD experience gastrointestinal symptoms, immune irregularities, and metabolic differences alongside neurological symptoms

Resveratrol attenuated TNF-alpha-induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway

However, only the reduced form acts as an antioxidant and performs the important functions

[DOI] [PubMed] [Google Scholar] 332.Liu G.H., Qu J., Shen X

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