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Under oxidative stress conditions, ROS or electrophiles interact with or modify KEAP1 cysteine (Cys) residues, resulting in conformational changes in the KEAP1 protein and subsequent disruption of the NRF2 DLG motif-KEAP1CUL3 complex
Class III, which includes the NAD+-dependent sirtuins (SIRTs)
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Alternatively, increase SubQ injection frequency rather than changing routes: twice-daily SubQ dosing maintains more stable plasma levels than once-daily IM without the tolerability issues
