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Therefore, to address whether p53 is involved in controlling the cellular tolerance to FA, we inactivated the gene coding for this factor ( TP53 ) and the one coding for ADH5 in HCT116 cells (Supplementary Fig
Given the crucial roles of ACSL5 and PPARG in fatty acid metabolism, we propose that the JAB1/CUL4B-ACSL5/PPARG axis may influence epithelial-mesenchymal transition (EMT) and stemness in breast cancer by regulating lipid metabolism
