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The latter can interact with superoxide (O 2 ) to form peroxynitrite (OONO ) and hydroxyl radical (OH ) that triggers poly(ADP-ribose) polymerase 1 activation, which initiates apoptosis

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much of this genetic variation concerns genes that are either thyroid-specific genes or are involved in autoimmunity, inflammation and/or cellular defense against stress (e.g., IL-1, IL-6, and TNF) [38]

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Optionally garnish with scallions on top
