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Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing

ARA 290 recipients and placebo patients exhibited no significant differences between chemistry and hematology values at baseline and wk 4

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Its key advantages are prolonged sterility (multi-dose use) and slight anesthetic effect, but it must be used correctly: always dilute drugs per guidelines, ensure the final solution is isotonic, and heed contraindications (no neonates, no intrathecal use)

Yu Y, Villalobos-Hernandez EC, Pradhananga S, Baker CC, Keating C, Grundy D, Lomax AE, Reed DE