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An elevated level of methylmalonic acid is reasonably specific for vitamin B12 deficiency, and the level always decreases with vitamin B12 therapy
It also acts at the level of bone marrow to stimulate erythropoiesis
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These studies have also shown that ICA-1s is specific to PKC -, leaving normal cells that do not overexpress PKC - largely unaffected 1,3
Due to difficulties in estimating indirect costs in hospitals associated with a particular diagnosis or procedure, Health Quality Ontario normally defaults to a consideration of direct treatment costs only
