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This group and others have shown that the High Mobility Globulin Box 1 Protein (HMGB1) is involved in the activation of RAGE in the RAGE pathway [1,2,52]

Total ROS Assay The plasma samples underwent analysis using a Total Reactive Oxygen Species (ROS) Assay Kit 520 nm (ThermoFisher, Waltham, MA, USA)

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It depends on the form

Melasma and post-inflammatory hyperpigmentation