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The most commonly reported side effect was mild headache, occurring at rates comparable to placebo

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It should be borne in mind that there are obvious differences between the physiologies of rodents and humans

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A 2026 review in the American Journal of Sports Medicine emphasizes that despite popularity, "significant research regarding the safety and efficacy of these therapeutic methods is required before definitive recommendations can be made to patients." Only a single human case series exists for BPC-157 (for knee pain), with significant methodological flaws and no controls