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The PARP-dependent nuclear translocation of AIFM1 from mitochondria induces DNA breakage, ultimately leading to cell death through the formation of an AIFM1-MIF complex

Bone marrow stem cell groups commonly used in experiments and clinical include hematopoietic stem cells (HSCs), c-kit + cells, SCA + cells, MSCs, and bone marrow-derived mononuclear cells (BMMNC) ( in vitro
That's a meaningful distinction, and it reflects decades of randomised controlled trials

Cell Host Microbe 25 , 404417.e6 (2019)
Normal growth and development in the absence of hepatic IGF-I