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These factors continuously stimulate the TLR and purinergic receptors (such as P2X7) of surrounding cells, creating a positive feedback loop that allows inflammation to amplify and trigger systemic acute inflammation (108, 109)

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Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls

Data availability All data generated or analyzed during this study are included in article and/or its supplementary material files

Edging is sometimes done by men seeking to increase their eventual orgasm intensity, but its also used as a tool for semen retention advocates