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The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man

After 3 months, volanesorsen markedly lowered plasma apoC-III ( 76%) and triglyceride ( 71%) concentrations, but increased plasma LDL cholesterol (+ 96%), which were sustained over 6 months of treatment

30 Some patients may derive psychologic benefits from local drug application, whereas others find the procedure cumbersome

Subjects were recruited by self-selection at Cleveland Clinic

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