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Mammalian cells cannot synthesize ascorbic acid de novo due to the lack of L-gulono-1,4 lactone oxidase, which is an essential enzyme for the production of ascorbic acid [1]

Judging from my personal experience, I believe that it played a role in reducing his weight loss

10.1074/jbc.274.41.28849 70 HayashiJ.CarverJ
Notably, 5 M IMP enhanced AHR activity approximately five-fold and sustained AHR activation, even between 0.1 and 0.01 M (Fig

Sharon G, Cruz NJ, Kang D-W, Gandal MJ, Wang B, Kim Y-M, et al
