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Even though, considering the essentiality of copper in humans, the copper hypothesis of GHK mechanism of action seems very attractive, recent gene data may challenge this mechanism and demand more studies into GHKs mechanism of action

doi: 10.1038/s41573-021-00233-1

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Cisplatin is an example of a drug whereby JNK activity is required for maximal cytotoxicity

10.7501/j.issn.0253-2670.2019.20.014 20 GhoshS.WhitleyC