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Consequently, neuronal survival depends heavily on the antioxidative functions of astrocytes, which engage in close metabolic crosstalk with neurons

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The secondary indicators apply to patients with mild or moderate alopecia and suggest upgrading the severity level if one or more of the following conditions are present: the alopecia significantly affects the patient's psychological or social wellbeing, there is substantial involvement of eyebrows or eyelashes, there is no notable improvement after at least 6 months of treatment, or the hair pull test is positive, indicating rapid disease progression