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Significant increase in water and food intake, variations in the absolute and relative weights of seminal vesicles, and effects noted in urinalysis evaluations were all deemed to be of no toxicological significance because they either represented a physiological response, were temporary and disappeared at the end of the recovery phase, or weren't associated with any microscopic alteration

doi: 10.1111/cpr.12080

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Collectively, these studies provide evidence that the L-carnitine system is differentially impacted by APOE genotypes with age and following L-carnitine challenge which could later contribute to AD pathogenesis through bioenergetics deficits, FA toxicity, and cerebrovascular dysfunction in E4s, especially in females

However, its effects on LVMI and markers of diastolic function are inconclusive