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In silico modeling revealed structural rearrangements that conceal the N-terminal hydrophobic loop, and molecular dynamics simulations predicted reduced binding free energy and weakened proteinlipid interactions
Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor
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Additionally, TFR1, acyl-CoA synthetase family member 2 (ACSF2), and heme oxygenase-1 (HO-1) expression were significantly upregulated, leading to increased ferroptosis in the optic nerves of locally demyelinated MS mice
DOSING OF BINDERS IS CRITICAL
