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Therefore, inhibiting NAMPT (for example, using KPT-9274) can selectively exhaust NAD pools in these niche-resident macrophages, thereby reversing their immunosuppressive phenotype and sensitizing the TME to immune checkpoint blockade

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References 1.Gurtner GC, Werner S, Barrandon Y, Longaker MT

Molecules like PTEN and Akt ensure proper metabolic reprogramming in T cells, and the appropriate balance of these signals promotes the stable development of functional Tregs