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One cysteine is enough: a monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx

Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E et al (2003)

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Conclusions Oxidative stress is a key driver of canine aging and chronic disease, primarily through damage to lipids, proteins, and DNA

siRNA sequences to knock down Hsf1 are: Antisense1: rCrUrUrGrArUrGrUrUrCrUrCrArArGrGrArGrCrUrGrCrUrCrCrUrG Sense1: rGrGrArGrCrArGrCrUrCrCrUrUrGrArGrArArCrArUrCrAAG Antisense2: rArArGrUrGrGrUrCrArCrUrGrArGrCrUrCrArUrUrCrUrUrGrUrCrC Sense2: rArCrArArGrArArUrGrArGrCrUrCrArGrUrGrArCrCrArCTT Negative control siRNA - IDT catalog no