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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Even if you're eating plenty of meat and dairy, your body might not be getting what it needs

Lebers disease

Expert Opin Emerg Drugs

The path forward For 5-amino-1mq to move from research compound to established therapy, human clinical trials are needed