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Sadly, many nootropics contain at least one ingredient with questionable research behind it
Barrier BPC-157 vs InfiniWell: Which Oral Delivery Technology Has Better Evidence

The potential pathogenic mechanisms underlying IC/BPS are diverse and can include bladder immune dysregulation, abnormalities in the nociceptive system, urothelial barrier dysfunction and even alterations in bladder microorganisms

Vision problems/abnormalities

Anyone using TB-500 should monitor liver enzymes and kidney function and work with a provider