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The pharmacological limitations to treating the overwhelming set of symptoms affecting patients with anxiety and depression have opened avenues to search for natural compounds and nutritional strategies [7]

doi:10.1126/science.1096502

Construction of the high-throughput screening method In order to further improve the enzyme activity of Ch PPK and its tolerance to the substrate phosphate polyP, we screened Ch PPK mutants that could efficiently use polyP in the ATP regeneration system to enhance the supply of ATP in the biocatalytic process