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doi: 10.1515/acph-2017-0023 233 De WaureCBertolaCBaccariniGChiavariniMMancusoC

Ketone bodies promote stem cell function, promote blood and lymph vessel function, moderate acute and chronic inflammation, reduce tissue fibrosis, protect against oxidative and hypoxic stress, and provide resiliency against hypoglycemia and energetic stress (Fig

Methods In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females ( n = 27

10.1038/s41556-018-0178-0 129 ZhangY.TanH.DanielsJ

Notably, the Hamilton Depression Rating Scale (HAMD-17) scores in this population correlate strongly with biomarkers of hepatic dysfunction (e.g., elevated gamma-glutamyl transferase) and neuronal injury (e.g., serum neurofilament light chain), suggesting a unique pathophysiology blending systemic and central nervous system (CNS) toxicity (Mirabdolhagh Hazaveh et al