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Funding This work was supported by NIH Grant CA-197713, the Sydney Frank Foundation, and the Kimmelman Fund as well as an MRC Unit grant (AJG)

Alongside TMAO, plasma levels of choline, betaine, and carnitine have also been used as predictors of adverse cardiac events and have been linked with an increased CVD risk, but their relevance and predictive value seem to be dependent on the serum levels of TMAO (Wang et al., 2014

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IDO1 inhibitors increase the number of CD4 + or CD8 + T cells, decrease Tregs, and block the expression of IDO1, CD47, and PD-L1, which inhibits HCC growth [118]

[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Devlin MJ, Robbins A, Cosman MN, Moursi CA, Cloutier AM, Louis L, Van Vliet M, Conlon C, Bouxsein ML