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Comprising ~40% of body weight and accounting for 26% of basal metabolic rate (Mathias, 2023)

When NLRP3 is activated, it can cleave the downstream inflammatory factor IL-1 from the precursor to the mature state and release it into the extracellular space, which causes neuroinflammation (Heneka et al., 2018)

Another approach uses 5-amino-1MQ during breaks

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