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Closed systems, such as photobioreactors and fermenters, on the other hand, provide more control over the culturing conditions than the open systems

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But several factors work against this natural recovery process, including age (collagen production drops roughly 1% per year after age 20), the amount of weight lost (more than 50 pounds creates significantly more laxity), how long the excess weight was carried, sun damage history, smoking, genetics, and the speed at which the weight came off

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