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These toxicities may be due to kratom/mitragynine, but the blood concentrations of mitragynine varied considerably (0.020.18 g/g)

Furthermore, it has been suggested that the effects of cuprizone on oligodendrocyte metabolism are related to a Schiff base formation binding with the amino acid metabolism coenzyme pyridoxal 5-phosphate, and completely independent of copper chelation 18

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Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: a secondary analysis of a prospective randomized trial