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In the open trial, which aimed to test the clinical efficacy of creatine supplementation in a large cohort of patients, myopathies included muscle dystrophies ( n = 15), mitochondrial cytopathies ( n = 17), inflammatory myopathies ( n = 14), and peripheral neuropathy disorders ( n = 18), whereas the single-blinded study was conducted only on 21 heterogeneous patients ( n = 16, miscellaneous myopathies, n = 6 muscle dystrophies, n = 1 peripheral neuropathy disorder, and n = 1 inflammatory myopathy [53]

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