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Description
Betaine, also known as trimethylglycine, is a naturally occurring metabolite that serves as a methyl donor and osmolyte in the body

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L-Carnitine supplementation an lead to improvements in several complications seen in uremic patients, including cardiac complications, impaired exercise and functional capacities, muscle symptoms, increased symptomatic intradialytic hypotension, and erythropoietin-resistant anemia through normalizing the reduced carnitine palmitoyl transferase activity in red cells [43]

doi: 10.1016/j.jmig.2014.08.210 388 TsolakidisDPadosGVavilisDAthanatosDTsalikisTGiannakouAet al

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS
