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Graphical Abstract Schematic illustration of the proposed molecular mechanism highlights the role of dihydromyricetin (DHM) in the pathophysiology of SCI and subsequent motor function recovery

The discovery of lactylation, a novel post-translational modification, has uncovered the role of lactate in regulating diseases, especially in the brain

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Mechanistic modeling of the MAT2ASRFPARN axis reveals a SAM-independent pathway that stabilizes SRF, drives glycolysis through PI3K/AKT activation, and promotes osteosarcoma progression, highlighting MAT2A as a therapeutic target.

For in silico analysis, we screened two public datasets, GSEA M5190 and TCGA SARC