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B12 injections may also be useful for those with gastrointestinal issues, older adults, vegans, vegetarians, and people with underlying health conditions that can restrict vitamin B12 absorption
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They are potentially safer for long-term use because they work through natural biological mechanisms rather than forcing pathways shut

doi: 10.1073/pnas.83.9.2797

The receptor internalization and sequestration into endo-some [25] result from the -arrestin bound receptor
