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Lifestyle factors such as aging, stress, diet, and environmental exposure may affect natural glutathione levels, making supplementation a helpful addition for some individuals

PLoS One 8 (9), e75686

However, due to the existence of drug resistance mechanism of tumor cells, the efficacy of chemotherapeutic drugs will also be affected by drug resistance during the treatment of gastric cancer patients [5]

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Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency