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Description
Retatrutide (Eli Lilly) and CagriSema (Novo Nordisk) represent different approaches to the same goal: achieving weight loss approaching bariatric surgery without the scalpel
This investigational peptide mimics the natural hormone amylin (also known as islet amyloid polypeptide or IAPP), which plays a crucial role in glucose homeostasis and satiety regulation [1]

It is frequently used in anti-aging contexts to reduce age spots and improve skin elasticity

& Xie, S.-P

Theoretical synergy exists: cagrilintide reduces caloric intake via satiety prolongation, tesofensine increases caloric expenditure via thermogenesis, and the combination could produce additive weight loss without overlapping side-effect profiles
