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Description
Norris recommends vegan adults 18 to 65 years old should take one of the following regimens: two doses per day of 2 to 3.5 mcg per serving, one dose per day of 25 to 100 mcg per serving, or two doses per week of 1,000 mcg per serving

Antioxidants help fight unstable free-radical molecules, or molecules that may damage your skin cells

NAD+ metabolism and its roles in cellular processes during ageing

doi: 10.1227/01.neu.0000255525.34956.3f

While this isn't a definitive indicator, it's worth considering in conjunction with other signs of expiration
