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Our results showed increase in levels of these metabolites intracellularly and in culture supernatants

Interpreting limits of past ULT trials A guiding doctrine of the ACP guideline was that retrospective studies and even RCTs that used the decline in serum urate level to a pre-stipulated target as an indirect, surrogate outcome, rather than demonstrating the improvement in a clinical outcome such as reduction in frequency of acute gout flares during the randomized phase of an RCT, were insufficient data for the standard of evidence-based guidelines defined by the Institute of Medicine (since renamed the National Academy of Medicine) 40

10.1111/and.13646 [DOI] [PubMed] [Google Scholar] 8.Colagar AH, Marzony ET, Chaichi MJ

The ScanR and confocal imaging was performed at the Cellular and Molecular Imaging Core Facility (CMIC), NTNU

Rodriques, S