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Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA
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Most clinical studies suggest that daily doses of up to 2,000mg to 3,000mg are well-tolerated
Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism, link: 38
