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Lundgreen et al., Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines

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J Drug Assess

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Additionally, rhein alleviates desmoplastic anemia and EMT by influencing the Ras-related C3 botulinum toxin substrate 1/NOX1/-catenin signaling pathway ( Interestingly, rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis (Zhang et al., 2016), and it also provides renal protection through the regulation of DNA methyltransferases expression and methylation at the Klotho promoter (Zhang et al., 2017)

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doi: 10.1016/0076-6879(95)51107-5 63

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