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Authors relationships and activities The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work

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Patients with Known or Suspected Mitochondrial Disease Valproate is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [see Contraindications (4)]

given the short duration of PFOS exposure (e.g., 1, 4, 6 and 24 h) to RTCs, the concentration that was used in our study was approximately four times that of the PFOS concentration that fluorochemical production workers are exposed to