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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

Skog, 2005

Physiol Rep 4:e12913

Both windows correspond to elevated insulin sensitivity and low circulating insulin, maximizing IGF-1 receptor availability

J Biol Chem 267:2180221807 Morales J, Kadota Y, Zipfel C, Molina A, Torres MA (2016) The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity