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Mechanistically, hyperoside inhibits fatty acid and triglyceride synthesis via the FXRSCD1/SREBP1 axis, while independently suppressing ATP-citrate lyase (ACLY), thereby reducing acetyl-coenzyme A availability at its source and synergistically attenuating lipid accumulation (58)

Ketogenesis occurs in the liver, specifically, in hepatocytes, through the mitochondrial -oxidation of fatty acids

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By integrating and critically evaluating the available evidence, this review seeks to provide a theoretical foundation and a reference framework for the scientific application of hawthorn in the prevention and management of lipid metabolism-related diseases, as well as for future research endeavors