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Prkacin I, Separovic J, Aralica G, et al

Mechanistic reviews by Chelakkot et al., published in Experimental & Molecular Medicine (2018) , describe how dysregulation of these junctions is associated with increased intestinal permeability and immune activation

Mechanosensitive enteric neurons in the myenteric plexus of the mouse intestine

336,337 Expression of antioxidants either fails to be induced or is decreased, allowing increased expression of reactive oxygen species to affect tubulointerstitial fibrosis through necrosis, apoptosis, activation of interstitial fibroblasts and pericytes, proliferation of endothelial cells, and epithelial-mesenchyme transition (figure 1)

The Norwegian-Danish Study Group