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Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity

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As described above, Y211 plays multiple roles in the substrate binding site, forming a large part of the pocket surface and also binding solvent

*Correspondence: Alfredo Gimnez-Cassina [email protected] Present address: Daro Garca-Rodrguez, Instituto de Biologa Funcional y Genmica (IBFG USAL-CSIC), Universidad de Salamanca, Salamanca, Spain Specialty section : This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers