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The Hh pathway plays an important role in maintaining quiescence, self-renewal, survival, and chemoresistance of BCR-ABL + LSCs ( + leukemia cells and can activate downstream glioma-associated oncoprotein (GLI) transcription factors to maintain the dormancy and chemoresistance of LSCs ( + leukemia cells, induce dormant LSCs into the cell cycle, reduce leukemia initiation, and exert synergistic effects with cytarabine (AraC) ( Table 1 )
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Do not double-dose or inject in the morning to 'make up' for the miss
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