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The crucial mechanism seems to be the impaired sympathetic and parasympathetic balance ( The current literature indicates the role of immature neuronal networks and brainstem immaturity, which would induce altered cardiorespiratory autonomic control, irregular breathing, increased cardiac electrical instability and susceptibility to arrhythmias

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The multifactorial nature of CRF also explains why there is no simple cure effective management usually requires a comprehensive , interdisciplinary strategy addressing both the body and mind

Additionally, it is used in investigations pertaining to muscle physiology and metabolism, where its effects on exercise performance and recovery are explored