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Description
It is induced by mutations in the gene encoding 3-hydroxysterol- 7 -reductase (DHCR7), the enzyme catalyzing cholesterol formation by 7-dehydrocholesterol reduction

The excess production of ROS is one of the main molecular causes that contributes to varicocele-related male infertility, in which MIR210HG and MLLT4-AS1 (hypoxia-related lncRNAs) also showed significant positive correlations with ROS and negative correlations with sperm count and motility [48]

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This pearl is partly based on findings from a retrospective review of 160 patients who took one course of isotretinoin compared with 82 patients who underwent two courses

2012;7(5):e37883
