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10.1016/j.carpath.2015.11.001 18 GuH

N.SparanoJ
The underlying meta-level parameters, such as nutritional value, composition, nutritional effects, metabolism, etc., used in determining substantial equivalence are philosophically derived from performance parameters used for medical devices and hardware systems, which may not meet the needs for assessing the equivalence of biological organisms

To complicate things, some findings have reported that GLP-1 RAs might reduce testosterone pulses (the natural rhythm in how testosterone is released) or delay recovery of sperm functionality after stopping the medication. One small study in animals suggested that liraglutide impaired semen parameters temporarily, though sperm quality seemed to improve after stopping the drug

Supplementing it intravenously restores balance and provides multiple benefits
