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Ketamine is endowed with a peculiar profile with multiple pharmacological activities that may result from different underlying mechanisms

J Endocrinol 180:183191 Proneth B, Portillo FP, Haskell-Luevano C (2009) A combination of ligand Sar and receptor site-directed mutagenesis reveals requirements for antagonist activity at the melanocortin-3 receptor

10 Lentigines on sun-damaged skin or in the setting of xeroderma pigmentosum have been associated with melanoma, 11-13 but genital lentigines are not considered a form of precancerous melanosis

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