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When oxidative stress occurs, it can lead to inflammation, fibrosis, and even cirrhosis over time

Notably, in addition to trying to block potential downstream detrimental effects, new therapies need to be designed that preserve and boost astrocytic defences and improve astrocytic homoeostasis

Some aggregation-prone proteins are acetylated, including huntingtin, tau protein, superoxide dismutase 1 (SOD1), and TDP-43, which affects their aggregation

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