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Adult height in children with growth hormone deficiency: a randomized, controlled, growth hormone dose-response trial

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Clinically, IGF-1 and derivatives are used to treat patients who suffer from muscle wasting due to conditions like HIV, as well as patients with hormonal disorders [2]

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It regulates growth hormone (GH) synthesis and secretion via cyclic AMP Protein Kinase A (cAMP-PKA) and mitogen-activated protein kinase (MAPK) signaling pathways, enhancing pituitary transcription factor 1 (Pit-1) levels and subsequently increasing GH gene expression [1,2,3,4,5]